Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.

Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.

p53 protects us from cancer by transcriptionally regulating tumor suppressive programs designed to either prevent the development or clonal expansion of malignant cells. How p53 selects target genes in the genome in a context- and tissue-specific manner remains largely obscure. There is growing evid...

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Bibliographic Details
Main Authors: Katharina Schlereth, Charlotte Heyl, Anna-Maria Krampitz, Marco Mernberger, Florian Finkernagel, Maren Scharfe, Michael Jarek, Ellen Leich, Andreas Rosenwald, Thorsten Stiewe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3744428?pdf=render

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http://europepmc.org/articles/PMC3744428?pdf=render

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