Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I

The convenient synthesis of a library of novel 6,6,5-tricyclic thiazolo[5,4-f] quinazolines (forty molecules) was achieved mainly under microwave irradiation. Dimroth rearrangement and 4,5-dichloro-1,2,3,-dithiazolium chloride (Appel salt) chemistry were associated for the synthesis of a novel 6-ami...

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Bibliographic Details
Main Authors: Alicia Foucourt, Damien Hédou, Carole Dubouilh-Benard, Laurent Désiré, Anne-Sophie Casagrande, Bertrand Leblond, Nadège Loäec, Laurent Meijer, Thierry Besson
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Molecules
Subjects:
thiazolo[5,4-f]quinazolines
kinases inhibitors
DYRK1A
GSK3α/β
microwave-assisted chemistry
Dimroth rearrangement
appel salt
Online Access:http://www.mdpi.com/1420-3049/19/10/15546

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http://www.mdpi.com/1420-3049/19/10/15546

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