Preclinical Pharmacokinetic and Safety Studies of Copper-Diacetyl-Bis(N4-Methylthiosemicarbazone) (Cu-ATSM): Translational Studies for Internal Radiotherapy

Preclinical Pharmacokinetic and Safety Studies of Copper-Diacetyl-Bis(N4-Methylthiosemicarbazone) (Cu-ATSM): Translational Studies for Internal Radiotherapy

Hypoxia plays important roles in the prognosis of malignant brain tumors such as glioblastoma because it causes drug delivery deficiencies and the induction of hypoxia-inducible factor-1α in tumor cells. Extensive hypoxic areas are associated with poor prognosis of these fatal diseases. We previousl...

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Bibliographic Details
Main Authors: Hiroki Matsumoto, Yukie Yoshii, Atsumi Baden, Emi Kaneko, Hiroki Hashimoto, Hisashi Suzuki, Kazunori Kawamura, Ming-Rong Zhang, Tatsuya Higashi, Hiroaki Kurihara
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523319301020

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http://www.sciencedirect.com/science/article/pii/S1936523319301020

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