Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice.

Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice.

Angiotensin-converting enzyme (ACE) regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-system (RAS). Ace-/- mice are smaller in size, have low blood pressure and defective kidney structure and functions. All of these defects are cured by transgenic expr...

Full description

Bibliographic Details
Main Authors: Saurabh Chattopadhyay, Sean P Kessler, Juliana Almada Colucci, Michifumi Yamashita, Preenie deS Senanayake, Ganes C Sen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903672?pdf=render

Internet

http://europepmc.org/articles/PMC3903672?pdf=render

Similar Items