PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.
Two genes linked to early onset Parkinson's disease, PINK1 and Parkin, encode a protein kinase and a ubiquitin-ligase, respectively. Both enzymes have been suggested to support mitochondrial quality control. We have reported that Parkin is phosphorylated at Ser65 within the ubiquitin-like domai...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-06-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4046931?pdf=render |