Discordant amyloid-β PET and CSF biomarkers and its clinical consequences

Discordant amyloid-β PET and CSF biomarkers and its clinical consequences

Abstract Background In vivo, high cerebral amyloid-β load has been associated with (i) reduced concentrations of Aβ42 in cerebrospinal fluid and (ii) increased retention using amyloid-β positron emission tomography. Although these two amyloid-β biomarkers generally show good correspondence, ~ 10–20%...

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Bibliographic Details
Main Authors: Arno de Wilde, Juhan Reimand, Charlotte E. Teunissen, Marissa Zwan, Albert D. Windhorst, Ronald Boellaard, Wiesje M. van der Flier, Philip Scheltens, Bart N. M. van Berckel, Femke Bouwman, Rik Ossenkoppele
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Alzheimer’s Research & Therapy
Subjects:
Subjective cognitive decline
Mild cognitive impairment
Dementia
Alzheimer’s disease
Positron emission tomography
Cerebrospinal fluid
Online Access:http://link.springer.com/article/10.1186/s13195-019-0532-x

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http://link.springer.com/article/10.1186/s13195-019-0532-x

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