PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis

PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis

The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2]. Here, we used RNA interference to search for regulators of P...

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Bibliographic Details
Main Authors: Ao Hu, Xue-Tong Zhao, Heng Tu, Ting Xiao, Ting Fu, Yan Wang, Yong Liu, Xiong-Jie Shi, Jie Luo, Bao-Liang Song
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter D1
lysosomes
lysosome-peroxisome membrane contact
Syt7
synaptotagmin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520331382

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http://www.sciencedirect.com/science/article/pii/S0022227520331382

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