Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures

Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures

Mutations of the voltage-gated sodium (Nav) channel subunit SCN1A have been implicated in the pathogenesis of human febrile seizures including generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy in infancy (SMEI). Hyperthermia-induced seizure-susceptible (Hiss) rats...

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Bibliographic Details
Main Authors: Yukihiro Ohno, Shizuka Ishihara, Tomoji Mashimo, Nobumasa Sofue, Saki Shimizu, Takuji Imaoku, Toshiko Tsurumi, Masashi Sasa, Tadao Serikawa
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
Febrile seizure
Nav1.1 channel
Scn1a
Missense mutation
Rat model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003141

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http://www.sciencedirect.com/science/article/pii/S0969996110003141

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