Phenotypic Identification of the Redox Dye Methylene Blue as an Antagonist of Heat Shock Response Gene Expression in Metastatic Melanoma Cells

Phenotypic Identification of the Redox Dye Methylene Blue as an Antagonist of Heat Shock Response Gene Expression in Metastatic Melanoma Cells

Repurposing approved and abandoned non-oncological drugs is an alternative developmental strategy for the identification of anticancer therapeutics that has recently attracted considerable attention. Due to the essential role of the cellular heat shock response in cytoprotection through the maintena...

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Bibliographic Details
Main Authors: Georg T. Wondrak, Christopher M. Cabello, Sara Azimian, Shuxi Qiao, Angela L. Davis
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:International Journal of Molecular Sciences
Subjects:
malignant melanoma
heat shock response
Hsp70
Hsp27
methylene blue
chemosensitization
Online Access:http://www.mdpi.com/1422-0067/14/2/4185

Internet

http://www.mdpi.com/1422-0067/14/2/4185

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