Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative

Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative

The syntheses of C-13 epimeric 3-[(1-benzyl-1,2,3-triazol-4-yl)methoxy]-d-secoestrones are reported. Triazoles were prepared from 3-(prop-2-inyloxy)-d-secoalcohols and p-substituted benzyl azides via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The antiproliferative activities of the products...

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Bibliographic Details
Main Authors: Johanna Szabó, Nóra Jerkovics, Gyula Schneider, János Wölfling, Noémi Bózsity, Renáta Minorics, István Zupkó, Erzsébet Mernyák
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
antiproliferative effect
azide-alkyne cycloaddition
">d-secoestrone
triazole
Online Access:http://www.mdpi.com/1420-3049/21/5/611

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http://www.mdpi.com/1420-3049/21/5/611

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