IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila

IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila

Legionella pneumophila is one example among many species of pathogenic bacteria that replicate within mammalian macrophages during infection. The immune signaling factor interferon gamma (IFN-γ) blocks L. pneumophila replication in macrophages and is an essential component of the immune response to...

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Bibliographic Details
Main Authors: Jordan V. Price, Daniel Russo, Daisy X. Ji, Roberto A. Chavez, Lucian DiPeso, Angus Yiu-Fai Lee, Jörn Coers, Russell E. Vance
Format: Article
Language:English
Published: American Society for Microbiology 2019-11-01
Series:mBio
Subjects:
legionella pneumophila
host-pathogen interactions
innate immunity
interferons
macrophages
Online Access:https://doi.org/10.1128/mBio.02629-19

Internet

https://doi.org/10.1128/mBio.02629-19

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