Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

Central nervous system (CNS) inflammatory processes including microglial activation have been implicated in the pathogenesis of neurodegenerative diseases such as Huntington Disease (HD). We report age-dependent changes in striatal microglial morphology and vasculature in the YAC128 mouse model of H...

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Bibliographic Details
Main Authors: Sonia Franciosi, Jae K. Ryu, Yaein Shim, Austin Hill, Colum Connolly, Michael R. Hayden, James G. McLarnon, Blair R. Leavitt
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
Huntington disease
YAC128
Microglia
Neurovasculature
Cytokine
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003007

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http://www.sciencedirect.com/science/article/pii/S0969996111003007

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