Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic forms of PD, suggesting this protei...

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Main Authors: Diana F Lázaro, Eva F Rodrigues, Ramona Langohr, Hedieh Shahpasandzadeh, Thales Ribeiro, Patrícia Guerreiro, Ellen Gerhardt, Katharina Kröhnert, Jochen Klucken, Marcos D Pereira, Blagovesta Popova, Niels Kruse, Brit Mollenhauer, Silvio O Rizzoli, Gerhard H Braus, Karin M Danzer, Tiago F Outeiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4230739?pdf=render

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http://europepmc.org/articles/PMC4230739?pdf=render

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