Highly selective inhibition of Bruton’s tyrosine kinase attenuates skin and brain disease in murine lupus

Highly selective inhibition of Bruton’s tyrosine kinase attenuates skin and brain disease in murine lupus

Abstract Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects different end organs, including skin and brain. We and others have previously shown the importance of macrophages in the pathogenesis of cutaneous and neuropsychiatric lupus. Additionally, autoantibo...

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Main Authors: Samantha A. Chalmers, Jing Wen, Jessica Doerner, Ariel Stock, Carla M. Cuda, Hadijat M. Makinde, Harris Perlman, Todd Bosanac, Deborah Webb, Gerald Nabozny, Jay S. Fine, Elliott Klein, Meera Ramanujam, Chaim Putterman
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Arthritis Research & Therapy
Subjects:
Systemic lupus erythematous (SLE)
Neuropsychiatric lupus (NPSLE)
Cutaneous lupus erythematosus (CLE)
Bruton’s tyrosine kinase (BTK)
Online Access:http://link.springer.com/article/10.1186/s13075-017-1500-0

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http://link.springer.com/article/10.1186/s13075-017-1500-0

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