Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

Lewy bodies (LBs) are the characteristic inclusions of Parkinson's disease brain but the mechanism responsible for their formation is obscure. Lewy bodies (LBs) are composed of a number of proteins of which alpha-synuclein (α-SYN) is a major constituent. In this study, we have investigated the...

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Bibliographic Details
Main Authors: Rina Bandopadhyay, Ann E. Kingsbury, Miratul M. Muqit, Kirsten Harvey, Andrew R. Reid, Linda Kilford, Simone Engelender, Michael G. Schlossmacher, Nicholas W. Wood, David S. Latchman, Robert J. Harvey, Andrew J. Lees
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Synphilin-1
Parkin
Lewy bodies
Distribution
Immunohistochemistry
Immunoelectron microscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000926

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http://www.sciencedirect.com/science/article/pii/S0969996105000926

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