A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

Abstract In Alzheimer’s disease (AD) and related tauopathies, the microtubule-associated protein tau is highly phosphorylated and aggregates to form neurofibrillary tangles that are characteristic of these neurodegenerative diseases. Our previous work has demonstrated that the thousand-and-one amino...

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Bibliographic Details
Main Authors: Caterina Giacomini, Chuay-Yeng Koo, Natalia Yankova, Ignatius A. Tavares, Selina Wray, Wendy Noble, Diane P. Hanger, Jonathan D. H. Morris
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer
Tauopathy
Dementia
TAOK
Tau
Phosphorylation
Online Access:http://link.springer.com/article/10.1186/s40478-018-0539-8

Internet

http://link.springer.com/article/10.1186/s40478-018-0539-8

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