Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling

Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling

Loss-of-function (LOF) variants in SCN1B, encoding voltage-gated sodium channel β1 subunits, are linked to human diseases with high risk of sudden death, including developmental and epileptic encephalopathy and cardiac arrhythmia. β1 Subunits modulate the cell-surface localization, gating, and kinet...

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Bibliographic Details
Main Authors: Alexandra A. Bouza, Nnamdi Edokobi, Samantha L. Hodges, Alexa M. Pinsky, James Offord, Lin Piao, Yan-Ting Zhao, Anatoli N. Lopatin, Luis F. Lopez-Santiago, Lori L. Isom
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-02-01
Series:JCI Insight
Subjects:
Cardiology
Cell biology
Online Access:https://doi.org/10.1172/jci.insight.141776

Internet

https://doi.org/10.1172/jci.insight.141776

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