Kinesin-4 KIF21B is a potent microtubule pausing factor

Kinesin-4 KIF21B is a potent microtubule pausing factor

Microtubules are dynamic polymers that in cells can grow, shrink or pause, but the factors that promote pausing are poorly understood. Here, we show that the mammalian kinesin-4 KIF21B is a processive motor that can accumulate at microtubule plus ends and induce pausing. A few KIF21B molecules are s...

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Bibliographic Details
Main Authors: Wilhelmina E van Riel, Ankit Rai, Sarah Bianchi, Eugene A Katrukha, Qingyang Liu, Albert JR Heck, Casper C Hoogenraad, Michel O Steinmetz, Lukas C Kapitein, Anna Akhmanova
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
microtubule dynamics
Kinesin
EB1
Kinesin-4
KIF21B
pausing
Online Access:https://elifesciences.org/articles/24746

Internet

https://elifesciences.org/articles/24746

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