End binding proteins are obligatory dimers.

by Indrani Sen, Dmitry Veprintsev, Anna Akhmanova, Michel O Steinmetz
Published 2013-01-01

Remote control of microtubule plus-end dynamics and function from the minus-end

by Xiuzhen Chen, Lukas A Widmer, Marcel M Stangier, Michel O Steinmetz, Jörg Stelling, Yves Barral
Published 2019-09-01

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.

by Andrew B Waight, Katja Bargsten, Svetlana Doronina, Michel O Steinmetz, Django Sussman, Andrea E Prota
Published 2016-01-01

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocryst...

by Wolfgang Dohle, Andrea E. Prota, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz, Barry V. L. Potter
Published 2019-01-01

Structural basis for the oligomerization-state switch from a dimer to a trimer of an engineered cortexillin-1 coiled-coil variant.

by Saša Bjelić, Mara Wieser, Daniel Frey, Christian U Stirnimann, Mark R Chance, Rolf Jaussi, Michel O Steinmetz, Richard A Kammerer
Published 2013-01-01

Abstract OR-8: High-Resolution Structures of Microtubule-Drug Complexes Revealed by Cryo-EM

by Kushal Sejwal, Thorsten B. Blum, Joseph Atherton, Ashwani Sharma, Natacha Olieric, Andrea E. Prota, Carolyn A. Moores, Michel O. Steinmetz
Published 2019-06-01

Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin

by Ashwani Sharma, Gonzalo Sáez-Calvo, Natacha Olieric, Francisco de Asís Balaguer, Isabel Barasoain, Clemens Lamberth, J. Fernando Díaz, Michel O. Steinmetz
Published 2017-06-01

The mechanism of kinesin inhibition by kinesin-binding protein

by Joseph Atherton, Jessica JA Hummel, Natacha Olieric, Julia Locke, Alejandro Peña, Steven S Rosenfeld, Michel O Steinmetz, Casper C Hoogenraad, Carolyn A Moores
Published 2020-11-01

Kinesin-4 KIF21B is a potent microtubule pausing factor

by Wilhelmina E van Riel, Ankit Rai, Sarah Bianchi, Eugene A Katrukha, Qingyang Liu, Albert JR Heck, Casper C Hoogenraad, Michel O Steinmetz, Lukas C Kapitein, Anna Akhmanova
Published 2017-03-01

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

by Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, Pascal Bucher, Rolf Jansen, Herbert Irschik, Rolf Müller, Ian Paterson, J. Fernando Díaz, Karl-Heinz Altmann, Michel O. Steinmetz
Published 2018-05-01

WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity

by Emmanuelle Steib, Marine H Laporte, Davide Gambarotto, Natacha Olieric, Celine Zheng, Susanne Borgers, Vincent Olieric, Maeva Le Guennec, France Koll, Anne-Marie Tassin, Michel O Steinmetz, Paul Guichard, Virginie Hamel
Published 2020-09-01

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

by Joseph Atherton, Yanzhang Luo, Shengqi Xiang, Chao Yang, Ankit Rai, Kai Jiang, Marcel Stangier, Annapurna Vemu, Alexander D. Cook, Su Wang, Antonina Roll-Mecak, Michel O. Steinmetz, Anna Akhmanova, Marc Baldus, Carolyn A. Moores
Published 2019-11-01

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells

by Chiara Trigili, Isabel Barasoain, Pedro A. Sánchez-Murcia, Katja Bargsten, Mariano Redondo-Horcajo, Aurora Nogales, Nicola M. Gardner, Arndt Meyer, Guy J. Naylor, Elena Gómez-Rubio, Federico Gago, Michel O. Steinmetz, Ian Paterson, Andrea E. Prota, J. Fernando Díaz
Published 2016-12-01

Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site

by Christopher J. Smedley, Paul A. Stanley, Mohannad E. Qazzaz, Andrea E. Prota, Natacha Olieric, Hilary Collins, Harry Eastman, Andrew S. Barrow, Kuan-Hon Lim, Toh-Seok Kam, Brian J. Smith, Hendrika M. Duivenvoorden, Belinda S. Parker, Tracey D. Bradshaw, Michel O. Steinmetz, John E. Moses
Published 2018-07-01

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

by Francisco de Asís Balaguer, Tobias Mühlethaler, Juan Estévez-Gallego, Enrique Calvo, Juan Francisco Giménez-Abián, April L. Risinger, Erik J. Sorensen, Christopher D. Vanderwal, Karl-Heinz Altmann, Susan L. Mooberry, Michel O. Steinmetz, María Ángela Oliva, Andrea E. Prota, J. Fernando Díaz
Published 2019-03-01

Structural model for differential cap maturation at growing microtubule ends

by Juan Estévez-Gallego, Fernando Josa-Prado, Siou Ku, Ruben M Buey, Francisco A Balaguer, Andrea E Prota, Daniel Lucena-Agell, Christina Kamma-Lorger, Toshiki Yagi, Hiroyuki Iwamoto, Laurence Duchesne, Isabel Barasoain, Michel O Steinmetz, Denis Chrétien, Shinji Kamimura, J Fernando Díaz, Maria A Oliva
Published 2020-03-01

GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses

by Abhishek S. Kashyap, Laura Fernandez-Rodriguez, Yun Zhao, Gianni Monaco, Marcel P. Trefny, Naohiro Yoshida, Kea Martin, Ashwani Sharma, Natacha Olieric, Pankaj Shah, Michal Stanczak, Nicole Kirchhammer, Sung-Moo Park, Sebastien Wieckowski, Heinz Laubli, Rachid Zagani, Benjamin Kasenda, Michel O. Steinmetz, Hans-Christian Reinecker, Alfred Zippelius
Published 2019-09-01

Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

by Thomas Bohnacker, Andrea E. Prota, Florent Beaufils, John E. Burke, Anna Melone, Alison J. Inglis, Denise Rageot, Alexander M. Sele, Vladimir Cmiljanovic, Natasa Cmiljanovic, Katja Bargsten, Amol Aher, Anna Akhmanova, J. Fernando Díaz, Doriano Fabbro, Marketa Zvelebil, Roger L. Williams, Michel O. Steinmetz, Matthias P. Wymann
Published 2017-03-01

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

by Tobias Weinert, Natacha Olieric, Robert Cheng, Steffen Brünle, Daniel James, Dmitry Ozerov, Dardan Gashi, Laura Vera, May Marsh, Kathrin Jaeger, Florian Dworkowski, Ezequiel Panepucci, Shibom Basu, Petr Skopintsev, Andrew S. Doré, Tian Geng, Robert M. Cooke, Mengning Liang, Andrea E. Prota, Valerie Panneels, Przemyslaw Nogly, Ulrich Ermler, Gebhard Schertler, Michael Hennig, Michel O. Steinmetz, Meitian Wang, Jörg Standfuss
Published 2017-09-01

Advances in long-wavelength native phasing at X-ray free-electron lasers

by Karol Nass, Robert Cheng, Laura Vera, Aldo Mozzanica, Sophie Redford, Dmitry Ozerov, Shibom Basu, Daniel James, Gregor Knopp, Claudio Cirelli, Isabelle Martiel, Cecilia Casadei, Tobias Weinert, Przemyslaw Nogly, Petr Skopintsev, Ivan Usov, Filip Leonarski, Tian Geng, Mathieu Rappas, Andrew S. Doré, Robert Cooke, Shahrooz Nasrollahi Shirazi, Florian Dworkowski, May Sharpe, Natacha Olieric, Camila Bacellar, Rok Bohinc, Michel O. Steinmetz, Gebhard Schertler, Rafael Abela, Luc Patthey, Bernd Schmitt, Michael Hennig, Jörg Standfuss, Meitian Wang, Christopher J. Milne
Published 2020-11-01