NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD+ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.

Bibliographic Details
Main Authors: Evandro F. Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang, Tanima SenGupta, Domenica Caponio, Rojyar Khezri, Tyler G. Demarest, Yahyah Aman, David Figueroa, Marya Morevati, Ho-Joon Lee, Hisaya Kato, Henok Kassahun, Jong-Hyuk Lee, Deborah Filippelli, Mustafa Nazir Okur, Aswin Mangerich, Deborah L. Croteau, Yoshiro Maezawa, Costas A. Lyssiotis, Jun Tao, Koutaro Yokote, Tor Erik Rusten, Mark P. Mattson, Heinrich Jasper, Hilde Nilsen, Vilhelm A. Bohr
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13172-8

Internet

https://doi.org/10.1038/s41467-019-13172-8

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