The HIV co-receptor CCR5 regulates osteoclast function

The HIV co-receptor CCR5 regulates osteoclast function

CCR5 is a co-receptor for HIV, and loss of function is associated with lower incidence of HIV but also with bone-destructive diseases. Here the authors show that ablation of CCR5 impairs osteoclast function and improves resistance to osteoporosis in mouse models.

Bibliographic Details
Main Authors: Ji-Won Lee, Akiyoshi Hoshino, Kazuki Inoue, Takashi Saitou, Shunsuke Uehara, Yasuhiro Kobayashi, Satoshi Ueha, Kouji Matsushima, Akira Yamaguchi, Yuuki Imai, Tadahiro Iimura
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02368-5

Internet

https://doi.org/10.1038/s41467-017-02368-5

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