Huntington’s Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support

Huntington’s Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support

In Huntington’s disease (HD), while the ubiquitously expressed mutant Huntingtin (mtHTT) protein primarily compromises striatal and cortical neurons, glia also undergo disease-contributing alterations. Existing HD models using human induced pluripotent stem cells (iPSCs) have not extensively charact...

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Bibliographic Details
Main Authors: Veronica J. Garcia, David J. Rushton, Colton M. Tom, Nicholas D. Allen, Paul J. Kemp, Clive N. Svendsen, Virginia B. Mattis
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neuroscience
Subjects:
Huntington’s disease
astrocyte
neuron
iPSC
co-culture
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00669/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00669/full

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