PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).

PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).

Protein arginine methyltransferase-5 (PRMT5) is a Type II arginine methyltransferase that regulates various cellular functions. We hypothesized that PRMT5 plays a role in regulating the growth of human melanoma cells. Immunohistochemical analysis indicated significant upregulation of PRMT5 in human...

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Bibliographic Details
Main Authors: Courtney Nicholas, Jennifer Yang, Sara B Peters, Matthew A Bill, Robert A Baiocchi, Fengting Yan, Saïd Sïf, Sookil Tae, Eugenio Gaudio, Xin Wu, Michael R Grever, Gregory S Young, Gregory B Lesinski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3786975?pdf=render

Internet

http://europepmc.org/articles/PMC3786975?pdf=render

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