Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes.

Several major invasive bacterial pathogens are encapsulated. Expression of a polysaccharide capsule is essential for survival in the blood, and thus for virulence, but also is a target for host antibodies and the basis for effective vaccines. Encapsulated species typically exhibit antigenic variatio...

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Bibliographic Details
Main Authors: Stephen D Bentley, David M Aanensen, Angeliki Mavroidi, David Saunders, Ester Rabbinowitsch, Matthew Collins, Kathy Donohoe, David Harris, Lee Murphy, Michael A Quail, Gabby Samuel, Ian C Skovsted, Margit Staum Kaltoft, Bart Barrell, Peter R Reeves, Julian Parkhill, Brian G Spratt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1391919?pdf=render