MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

Metastasis is a major cause of cancer mortality. We generated an autochthonous transgenic mouse model whereby conditional expression of MYC and Twist1 enables hepatocellular carcinoma (HCC) to metastasize in >90% of mice. MYC and Twist1 cooperate and their sustained expression is required to...

Full description

Bibliographic Details
Main Authors: Renumathy Dhanasekaran, Virginie Baylot, Minsoon Kim, Sibu Kuruvilla, David I Bellovin, Nia Adeniji, Anand Rajan KD, Ian Lai, Meital Gabay, Ling Tong, Maya Krishnan, Jangho Park, Theodore Hu, Mustafa A Barbhuiya, Andrew J Gentles, Kasthuri Kannan, Phuoc T Tran, Dean W Felsher
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
metastasis
macrophages
cytokines
liver cancer
MYC
Twist1
Online Access:https://elifesciences.org/articles/50731

Internet

https://elifesciences.org/articles/50731

Similar Items