Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Abstract Traumatic brain injury (TBI) induces a wide variety of cellular and molecular changes that can continue for days to weeks to months, leading to functional impairments. Currently, there are no pharmacotherapies in clinical use that favorably modify the post-TBI outcome, due in part to limite...

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Bibliographic Details
Main Authors: Anssi Lipponen, Assam El-Osta, Antony Kaspi, Mark Ziemann, Ishant Khurana, Harikrishnan KN, Vicente Navarro-Ferrandis, Noora Puhakka, Jussi Paananen, Asla Pitkänen
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Acta Neuropathologica Communications
Subjects:
DNA methylation
LINCS analysis
MBD-seq
Recovery
RNA-seq
Treatment
Online Access:http://link.springer.com/article/10.1186/s40478-018-0519-z

Internet

http://link.springer.com/article/10.1186/s40478-018-0519-z

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