Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression

Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression

Inhibitors of DNA topoisomerase I (TOP1), an enzyme relieving torsional stress of DNA by generating transient single-strand breaks, are clinically used to treat ovarian, small cell lung and cervical cancer. As torsional stress is generated during transcription by progression of RNA polymerase II thr...

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Bibliographic Details
Main Authors: Tabea Riedlinger, Marek Bartkuhn, Tobias Zimmermann, Sandra B. Hake, Andrea Nist, Thorsten Stiewe, Michael Kracht, M. Lienhard Schmitz
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
cytokines
chemotherapy
TOP1 inhibitors
NF-κB
side-effects
infection
Online Access:https://www.mdpi.com/2072-6694/11/6/883

Internet

https://www.mdpi.com/2072-6694/11/6/883

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