T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein.

T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein.

Viral vectored vaccines have been shown to induce both T cell and antibody responses in animals and humans. However, the induction of even higher level T cell responses may be crucial in achieving vaccine efficacy against difficult disease targets, especially in humans. Here we investigate the oligo...

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Bibliographic Details
Main Authors: Emily K Forbes, Simone C de Cassan, David Llewellyn, Sumi Biswas, Anna L Goodman, Matthew G Cottingham, Carole A Long, Richard J Pleass, Adrian V S Hill, Fergal Hill, Simon J Draper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3440343?pdf=render

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http://europepmc.org/articles/PMC3440343?pdf=render

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