Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity.

Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity.

Prions, characterized by self-propagating protease-resistant prion protein (PrP) conformations, are agents causing prion disease. Recent studies generated several such self-propagating protease-resistant recombinant PrP (rPrP-res) conformers. While some cause prion disease, others fail to induce any...

Full description

Bibliographic Details
Main Authors: Fei Wang, Xinhe Wang, Christina D Orrú, Bradley R Groveman, Krystyna Surewicz, Romany Abskharon, Morikazu Imamura, Takashi Yokoyama, Yong-Sun Kim, Kayla J Vander Stel, Kumar Sinniah, Suzette A Priola, Witold K Surewicz, Byron Caughey, Jiyan Ma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5524416?pdf=render

Internet

http://europepmc.org/articles/PMC5524416?pdf=render

Similar Items