Activation of A2A Receptor by PDRN Reduces Neuronal Damage and Stimulates WNT/β-CATENIN Driven Neurogenesis in Spinal Cord Injury

Activation of A2A Receptor by PDRN Reduces Neuronal Damage and Stimulates WNT/β-CATENIN Driven Neurogenesis in Spinal Cord Injury

Spinal cord injury (SCI) is a complex clinical and progressive condition characterized by neuronal loss, axonal destruction and demyelination. In the last few years, adenosine receptors have been studied as a target for many diseases, including neurodegenerative conditions. The aim of this study was...

Full description

Bibliographic Details
Main Authors: Natasha Irrera, Vincenzo Arcoraci, Federica Mannino, Giovanna Vermiglio, Giovanni Pallio, Letteria Minutoli, Gianluca Bagnato, Giuseppe Pio Anastasi, Emanuela Mazzon, Placido Bramanti, Francesco Squadrito, Domenica Altavilla, Alessandra Bitto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
adenosine receptors
spinal cord injury
polydeoxyribonucleotide
inflammation
neurogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00506/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00506/full

Similar Items