Effects of Decomplexation Rates on Ternary Gene Complex Transfection with α-Poly(l-Lysine) or ε-Poly(l-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell

Effects of Decomplexation Rates on Ternary Gene Complex Transfection with α-Poly(l-Lysine) or ε-Poly(l-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell

The tight binding of pDNA with a cationic polymer is the crucial requirement that prevents DNA degradation from undesired DNase attack to safely deliver the pDNA to its target site. However, cationic polymer-mediated strong gene holding limits pDNA dissociation from the gene complex, resulting in a...

Full description

Bibliographic Details
Main Authors: Kyoungnam Kim, Kitae Ryu, Hana Cho, Min Suk Shim, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
decomplexation
pDNA release
α-poly(l-lysine)
ε-poly(l-lysine)
nuclear uptake
transfection difficulty
Online Access:https://www.mdpi.com/1999-4923/12/6/490

Internet

https://www.mdpi.com/1999-4923/12/6/490

Similar Items