Effects of Decomplexation Rates on Ternary Gene Complex Transfection with α-Poly(l-Lysine) or ε-Poly(l-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell
The tight binding of pDNA with a cationic polymer is the crucial requirement that prevents DNA degradation from undesired DNase attack to safely deliver the pDNA to its target site. However, cationic polymer-mediated strong gene holding limits pDNA dissociation from the gene complex, resulting in a...
Main Authors: | Kyoungnam Kim, Kitae Ryu, Hana Cho, Min Suk Shim, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-05-01
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Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/12/6/490 |
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