Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state

Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state

Human cytomegalovirus (HCMV) causes a lifelong infection through establishment of latency. Although reactivation from latency can cause life-threatening disease, our molecular understanding of HCMV latency is incomplete. Here we use single cell RNA-seq analysis to characterize latency in monocytes a...

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Bibliographic Details
Main Authors: Miri Shnayder, Aharon Nachshon, Batsheva Rozman, Biana Bernshtein, Michael Lavi, Noam Fein, Emma Poole, Selmir Avdic, Emily Blyth, David Gottlieb, Allison Abendroth, Barry Slobedman, John Sinclair, Noam Stern-Ginossar, Michal Schwartz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
cytomegalovirus
herpesvirus
latency
single-cell RNA-seq
reactivation
hematopoietic stem and progenitor cells
Online Access:https://elifesciences.org/articles/52168

Internet

https://elifesciences.org/articles/52168

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