T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination

T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination

Few current vaccines can establish antigen (Ag)-specific immune responses in both mucosal and systemic compartments. Therefore, development of vaccines providing defense against diverse infectious agents in both compartments is of high priority in global health. Intramuscular vaccination of an adeno...

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Bibliographic Details
Main Authors: Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
T helper 17 cells
cytotoxic T lymphocyte
vaccines
DNA vaccines
mucosal immunity
gut mucosa
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01456/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01456/full

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