Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets

Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets

Abstract Background Fluoroquinolones are broad-spectrum antibiotics used to prevent and treat a wide range of bacterial infections. Plasmid-mediated qnr genes provide resistance to fluoroquinolones in many bacterial species and are increasingly encountered in clinical settings. Over the last decade,...

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Bibliographic Details
Main Authors: Fredrik Boulund, Fanny Berglund, Carl-Fredrik Flach, Johan Bengtsson-Palme, Nachiket P. Marathe, DG Joakim Larsson, Erik Kristiansson
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Genomics
Subjects:
Qnr
Fluroquinolone resistance
Horizontal gene transfer
Hidden Markov models
Metagenomics
Online Access:http://link.springer.com/article/10.1186/s12864-017-4064-0

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http://link.springer.com/article/10.1186/s12864-017-4064-0

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