CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells

CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells

CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nano...

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Bibliographic Details
Main Authors: Kerstin Schütze, Katharina Petry, Julia Hambach, Niklas Schuster, William Fumey, Levin Schriewer, Jana Röckendorf, Stephan Menzel, Birte Albrecht, Friedrich Haag, Catelijne Stortelers, Peter Bannas, Friedrich Koch-Nolte
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
complement-dependent cytotoxicity
CD38
multiple myeloma
nanobody
heavy chain antibody
antibody engineering
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02553/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02553/full

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