RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature

RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature

IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B, o...

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Bibliographic Details
Main Authors: William R. Swindell, Maria A. Beamer, Mrinal K. Sarkar, Shannon Loftus, Joseph Fullmer, Xianying Xing, Nicole L. Ward, Lam C. Tsoi, Michelle J. Kahlenberg, Yun Liang, Johann E. Gudjonsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
epidermis
ETS1
IL-1
inflammatory bowel disease
keratinocytes
NF-kappaB
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00080/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00080/full

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