Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers

Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers

Gliomas and meningiomas are the most common brain neoplasms affecting both humans and canines, and identifying druggable targets conserved across multiple brain cancer histologies and comparative species could broadly improve treatment outcomes. While satisfactory cure rates for low grade, non-invas...

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Bibliographic Details
Main Authors: Lisa J. Schlein, Bahaa Fadl-Alla, Holly C. Pondenis, Stéphane Lezmi, Charles G. Eberhart, Amy K. LeBlanc, Peter J. Dickinson, Paul J. Hergenrother, Timothy M. Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Oncology
Subjects:
glioma
meningioma
brain cancer
procaspase-3
PAC-1
canine comparative
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00096/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00096/full

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