Intergenerational epigenetic inheritance of cancer susceptibility in mammals

Intergenerational epigenetic inheritance of cancer susceptibility in mammals

Susceptibility to cancer is heritable, but much of this heritability remains unexplained. Some ‘missing’ heritability may be mediated by epigenetic changes in the parental germ line that do not involve transmission of genetic variants from parent to offspring. We report that deletion of the chromati...

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Bibliographic Details
Main Authors: Bluma J Lesch, Zuzana Tothova, Elizabeth A Morgan, Zhicong Liao, Roderick T Bronson, Benjamin L Ebert, David C Page
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
epigenetics
transgenerational inheritance
histone modification
gametes
spermatogenesis
cancer
Online Access:https://elifesciences.org/articles/39380

Internet

https://elifesciences.org/articles/39380

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