Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis

Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a rapidly progressing disease with challenging management. To find novel effective therapies, better preclinical models are needed for the screening of anti-fibrotic compounds. Activated fibroblasts drive fibrogenesis and are the main cells...

Full description

Bibliographic Details
Main Authors: Sarah Rank Rønnow, Rand Qais Dabbagh, Federica Genovese, Carmel B. Nanthakumar, Vikki J. Barrett, Robert B. Good, Sarah Brockbank, Simon Cruwys, Henrik Jessen, Grith Lykke Sorensen, Morten Asser Karsdal, Diana Julie Leeming, Jannie Marie Bülow Sand
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Respiratory Research
Subjects:
Scar-in-a-jar
Fibrogenesis
IPF
Fibroblasts
Collagens
Extracellular matrix
Online Access:http://link.springer.com/article/10.1186/s12931-020-01369-1

Internet

http://link.springer.com/article/10.1186/s12931-020-01369-1

Similar Items