Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes.

Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes.

The single amino acid replacement Asp116His distinguishes the two subtypes HLA-B*2705 and HLA-B*2709 which are, respectively, associated and non-associated with Ankylosing Spondylitis, an autoimmune chronic inflammatory disease. The reason for this differential association is so far poorly understoo...

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Bibliographic Details
Main Authors: Elisa Nurzia, Daniele Narzi, Alberto Cauli, Alessandro Mathieu, Valentina Tedeschi, Silvana Caristi, Rosa Sorrentino, Rainer A Böckmann, Maria Teresa Fiorillo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3293911?pdf=render

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http://europepmc.org/articles/PMC3293911?pdf=render

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