A single-chain antibody generation system yielding CAR-T cells with superior antitumor function

A single-chain antibody generation system yielding CAR-T cells with superior antitumor function

With the aim of optimizing CAR-T cells for immunotherapy, Ochi et al. have established a system to generate and screen a library of CAR-T cells expressing different immunoglobulin variable regions. They show that this approach can enhance anti-tumour activities of CAR-T cells in vivo.

Bibliographic Details
Main Authors: Toshiki Ochi, Masaki Maruta, Kazushi Tanimoto, Fumitake Kondo, Toshihiro Yamamoto, Mie Kurata, Hiroshi Fujiwara, Junya Masumoto, Katsuto Takenaka, Masaki Yasukawa
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01791-1

Internet

https://doi.org/10.1038/s42003-021-01791-1

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