Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems

Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems

The heterogeneity of glioblastomas, the most common primary malignant brain tumor, remains a significant challenge for the treatment of these devastating tumors. Therefore, novel combination treatments are warranted. Here, we showed that the combined inhibition of TRAP1 by gamitrinib and histone dea...

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Bibliographic Details
Main Authors: Trang T. T. Nguyen, Yiru Zhang, Enyuan Shang, Chang Shu, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
glioblastoma
gamitrinib
HDAC inhibitors
tumor metabolism
electron transport chain
Bcl-2 family
Online Access:https://www.mdpi.com/2073-4409/9/7/1661

Internet

https://www.mdpi.com/2073-4409/9/7/1661

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