Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence

Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence

Arc is an activity-regulated neuronal protein, but little is known about its interactions, assembly into multiprotein complexes, and role in human disease and cognition. We applied an integrated proteomic and genetic strategy by targeting a tandem affinity purification (TAP) tag and Venus fluorescen...

Full description

Bibliographic Details
Main Authors: Esperanza Fernández, Mark O. Collins, René A.W. Frank, Fei Zhu, Maksym V. Kopanitsa, Jess Nithianantharajah, Sarah A. Lemprière, David Fricker, Kathryn A. Elsegood, Catherine L. McLaughlin, Mike D.R. Croning, Colin Mclean, J. Douglas Armstrong, W. David Hill, Ian J. Deary, Giulia Cencelli, Claudia Bagni, Menachem Fromer, Shaun M. Purcell, Andrew J. Pocklington, Jyoti S. Choudhary, Noboru H. Komiyama, Seth G.N. Grant
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
tandem affinity purification
PSD95
Arc
synaptic complexes
supercomplexes
genetic variants
cognition
intellectual disability
schizophrenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313359

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717313359

Similar Items