Down-regulation of CTLA-4 by HIV-1 Nef protein.

Down-regulation of CTLA-4 by HIV-1 Nef protein.

HIV-1 Nef protein down-regulates several cell surface receptors through its interference with the cell sorting and trafficking machinery. Here we demonstrate for the first time the ability of Nef to down-regulate cell surface expression of the negative immune modulator CTLA-4. Down-regulation of CTL...

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Bibliographic Details
Main Authors: Mohamed El-Far, Catherine Isabelle, Nicolas Chomont, Martin Bourbonnière, Simone Fonseca, Petronela Ancuta, Yoav Peretz, Younes Chouikh, Rabih Halwani, Olivier Schwartz, Joaquín Madrenas, Gordon J Freeman, Jean-Pierre Routy, Elias K Haddad, Rafick-Pierre Sékaly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3553160?pdf=render

Internet

http://europepmc.org/articles/PMC3553160?pdf=render

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