Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

While infrared nanospectroscopy methods based on thermomechanical detection (AFM-IR) enables the acquisition of absorption spectra at the nanoscale, single molecule detection has not been possible so far. Here, the authors present off-resonance, low power and short pulse infrared nanospectroscopy (O...

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Bibliographic Details
Main Authors: Francesco Simone Ruggeri, Benedetta Mannini, Roman Schmid, Michele Vendruscolo, Tuomas P. J. Knowles
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16728-1