Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity.

Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity.

BACKGROUND:Hepatic gene transfer, in particular using adeno-associated viral (AAV) vectors, has been shown to induce immune tolerance to several protein antigens. This approach has been exploited in animal models of inherited protein deficiency for systemic delivery of therapeutic proteins. Adequate...

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Bibliographic Details
Main Authors: Ashley T Martino, Sushrusha Nayak, Brad E Hoffman, Mario Cooper, Gongxian Liao, David M Markusic, Barry J Byrne, Cox Terhorst, Roland W Herzog
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2715858?pdf=render

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http://europepmc.org/articles/PMC2715858?pdf=render

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