Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis

Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons in the brainstem, spinal cord and motor cortex. ALS is characterized by genetic and clinical heterogeneity, suggesting the existence of genetic factors that modify the phenotypic expression o...

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Bibliographic Details
Main Authors: Laura Rué, Patrick Oeckl, Mieke Timmers, Annette Lenaerts, Jasmijn van der Vos, Silke Smolders, Lindsay Poppe, Antina de Boer, Ludo Van Den Bosch, Philip Van Damme, Jochen H. Weishaupt, Albert C. Ludolph, Markus Otto, Wim Robberecht, Robin Lemmens
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Neurodegeneration
Motor neuron
SOD1G93A
EphA4
Ephrin-A5
Online Access:http://link.springer.com/article/10.1186/s40478-019-0759-6

Internet

http://link.springer.com/article/10.1186/s40478-019-0759-6

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