Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease

Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease

R6/2 transgenic mice with expanded CAG repeats (>300) have a surprisingly prolonged disease progression and longer lifespan than prototypical parent R6/2 mice (carrying 150 CAGs); however, the mechanism of this phenotype amelioration is unknown. We compared gene expression profiles in the striatu...

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Bibliographic Details
Main Authors: Bin Tang, Tamara Seredenina, Giovanni Coppola, Alexandre Kuhn, Daniel H. Geschwind, Ruth Luthi-Carter, Elizabeth A. Thomas
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Striatum
Gene expression
Inclusion
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000623

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http://www.sciencedirect.com/science/article/pii/S0969996111000623

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