Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
The protein tyrosine phosphatase SHP2 is a key regulator of cell cycle control. Here the authors combine NMR measurements and X-ray crystallography and show that wild-type SHP2 dynamically exchanges between a closed inactive conformation and an open activated form and that the oncogenic E76K mutatio...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-06814-w |